Article
MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer.
Drug metabolism and pharmacokinetics - 1 Apr 2006
Komoto Chiho, Nakamura Tsutomu, Sakaeda Toshiyuki, Kroetz Deanna L, Yamada Toshio, Omatsu Hideaki, Koyama Tatsuya, Okamura Noboru, Miki Ikuya, Tamura Takao, Aoyama Nobuo, Kasuga Masato, Okumura Katsuhiko
Abstract excerpt
The genotype frequencies of MDR1 T-129C, C1236T, G2677A,T and C3435T SNPs were compared in 154 healthy Japanese and 100 healthy Caucasians to provide basic information on the inter-ethnic differences of pharmacotherapeutic outcome. The variants were found at allelic frequencies of 5.5%, 65.6%, 16.6%, 40.6% and 40.6%, for T-129C, C1236T, G2677A, G2677T and C3435T, respectively, in Japanese, and at 5.1%, 45.9%,...
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