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Article

MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.

Clinical pharmacology and therapeutics - 1 Apr 2006

Lamba Jatinder, Strom Stephen, Venkataramanan Raman, Thummel Kenneth E, Lin Yvonne S, Liu Wei, Cheng Cheng, Lamba Vishal, Watkins Paul B, Schuetz Erin

Abstract excerpt

OBJECTIVES: Variant cytochrome P450 (CYP) 3A4 alleles cannot explain human variation in CYP3A4 expression. This study investigated whether common single-nucleotide polymorphisms (SNPs) in multidrug resistance 1 (MDR1), encoding P-glycoprotein, or the pregnane X receptor (PXR) were associated with basal or inducible CYP3A4 expression. METHODS: MDR1 G2677T and C3435T SNPs and a PXR 6-base pair (bp) deletion were...

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Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Genes, MDR
Intestine, Small
Pregnane X Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Cytoplasmic and Nuclear

Receptors, Steroid

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PMID: 16580901
DOI: 10.1016/j.clpt.2005.11.013

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