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Article

The distribution of fitness effects of new beneficial mutations in Pseudomonas fluorescens.

Biology letters - 23 Feb 2011

McDonald Michael J, Cooper Tim F, Beaumont Hubertus J E, Rainey Paul B

Abstract excerpt

Theoretical studies of adaptation emphasize the importance of understanding the distribution of fitness effects (DFE) of new mutations. We report the isolation of 100 adaptive mutants-without the biasing influence of natural selection-from an ancestral genotype whose fitness in the niche occupied by the derived type is extremely low. The fitness of each derived genotype was determined relative to a single...

Topics

Gene Expression Regulation, Bacterial
Genetic Fitness
Mutation
Pseudomonas fluorescens
Selection, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20659918
DOI: 10.1098/rsbl.2010.0547
PMCID: PMC3030884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20659918-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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