Article
Cost of antibiotic resistance and the geometry of adaptation.
Molecular biology and evolution - 1 May 2012
Sousa Ana, Magalhães Sara, Gordo Isabel
Abstract excerpt
The distribution of effects of beneficial mutations is key to our understanding of biological adaptation. Yet, empirical estimates of this distribution are scarce, and its functional form is largely unknown. Theoretical models of adaptation predict that the functional form of this distribution should depend on the distance to the optimum. Here, we estimate the rate and distribution of adaptive mutations that...
Topics
- Anti-Bacterial Agents
- Drug Resistance, Bacterial
- Escherichia coli
- Evolution, Molecular
- Genetic Fitness
- Genome, Bacterial
- Microsatellite Repeats
- Models, Genetic
- Mutation
- Phenotype
- Selection, Genetic