Article
A quantitative trait locus for SBP maps near KCNB1 and PTGIS in a population isolate.
American journal of hypertension - 1 Jun 2009
Barbalić Maja, Narancić Nina Smolej, Skarić-Jurić Tatjana, Salihović Marijana Pericić, Klarić Irena Martinović, Lauc Lovorka Barać, Janićijević Branka, Farrall Martin, Rudan Igor, Campbell Harry, Wright Alan F, Hastie Nicholas D, Rudan Pavao
Abstract excerpt
BACKGROUND: Population isolates are characterized by simplified genetic background and as such present promising opportunities for studying complex diseases. We performed a genome-wide linkage analysis for systolic (SBP) and diastolic blood pressure (DBP) followed up by the association analysis in the Croatian isolated island of Vis, where a very high prevalence of hypertension was reported (75%). METHODS:...
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