Article
Genetic comparison of a Croatian isolate and CEPH European founders.
Genetic epidemiology - 1 Feb 2010
Navarro Pau, Vitart Véronique, Hayward Caroline, Tenesa Albert, Zgaga Lina, Juricic Danica, Polasek Ozren, Hastie Nicholas D, Rudan Igor, Campbell Harry, Wright Alan F, Haley Chris S, Knott Sara A
Abstract excerpt
Human isolates have been postulated as a good resource for the identification of QTL due to reduced genetic diversity and a more homogeneous environment. Isolates may also have increased linkage disequilibrium (LD) due to small effective population size and, either loss or increase in frequency of alleles that are rare in the general population from which they originate. Here we investigate the difference in...
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