Article
Genetic variation in CCDC93 is associated with elevated central systolic blood pressure, impaired arterial relaxation, and mitochondrial dysfunction.
PLoS genetics - 1 Sept 2024
Kumar Nitin, Yang Min-Lee, Sun Pengfei, Hunker Kristina L, Li Jianping, Jia Jia, Fan Fangfang, Wang Jinghua, Ning Xianjia, Gao Wei, Xu Ming, Zhang Jifeng, Chang Lin, Chen Y Eugene, Huo Yong, Zhang Yan, Ganesh Santhi K
Abstract excerpt
Genetic studies of blood pressure (BP) traits to date have been performed on conventional measures by brachial cuff sphygmomanometer for systolic BP (SBP) and diastolic BP, integrating several physiologic occurrences. Genetic associations with central SBP (cSBP) have not been well-studied. Genetic discovery studies of BP have been most often performed in European-ancestry samples. Here, we investigated genetic...
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