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Article

Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension: A SAPPHIRe Cohort Study.

Medicine - 1 Mar 2016

Chang Tien-Jyun, Wang Wen-Chang, Hsiung Chao A, He Chih-Tsueng, Lin Ming-Wei, Sheu Wayne Huey-Herng, Chang Yi-Cheng, Quertermous Tom, Chen Ida, Rotter Jerome, Chuang Lee-Ming

Abstract excerpt

Essential hypertension is a complex disease involving multiple genetic and environmental factors. A human gene containing a sorbin homology domain and 3 SH3 domains in the C-terminal region, termed SORBS1, plays a significant role in insulin signaling. We previously found a significant association between the T228A polymorphism and insulin resistance, obesity, and type 2 diabetes. It has been hypothesized that a...

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Identifiers

PMID: 26962801
DOI: 10.1097/MD.0000000000002970
PMCID: PMC4998882

Genes

SORBS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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