Article
Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium.
Human molecular genetics - 1 Jun 2011
Zhu Xiaofeng, Young J H, Fox Ervin, Keating Brendan J, Franceschini Nora, Kang Sunjung, Tayo Bamidele, Adeyemo Adebowale, Sun Yun V, Li Yali, Morrison Alanna, Newton-Cheh Christopher, Liu Kiang, Ganesh Santhi K, Kutlar Abdullah, Vasan Ramachandran S, Dreisbach Albert, Wyatt Sharon, Polak Joseph, Palmas Walter, Musani Solomon, Taylor Herman, Fabsitz Richard, Townsend Raymond R, Dries Daniel, Glessner Joseph, Chiang Charleston W K, Mosley Thomas, Kardia Sharon, Curb David, Hirschhorn Joel N, Rotimi Charles, Reiner Alexander, Eaton Charles, Rotter Jerome I, Cooper Richard S, Redline Susan, Chakravarti Aravinda, Levy Daniel
Abstract excerpt
Admixture mapping based on recently admixed populations is a powerful method to detect disease variants with substantial allele frequency differences in ancestral populations. We performed admixture mapping analysis for systolic blood pressure (SBP) and diastolic blood pressure (DBP), followed by trait-marker association analysis, in 6303 unrelated African-American participants of the Candidate Gene Association...
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