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Article

Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes

6 Mar 2009

Abstract excerpt

Excess food intake leads to obesity and diabetes, both of which are well-known independent risk factors for atherosclerosis, and both of which are growing epidemics in an aging population. We hypothesized that aging enhances the metabolic and vascular effects of high fat diet (HFD) and therefore examined the effect of age on atherosclerosis and insulin resistance in lipoprotein receptor knockout (LDLR(-/-)) mice....

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PMID: 19265038
DOI: 10.1161/circresaha.108.188771

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