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Article

A high-fat diet with vitamin D and propylthiouracil produces a pro-atherogenic phenotype in rats.

Animal models and experimental medicine - 1 May 2026

Lewies Angélique, Kodogo Vitaris, Wentzel Johannes Frederik, Smit Francis Edwin

Abstract excerpt

BACKGROUND: Atherosclerosis begins with dyslipidemia, vascular inflammation, and endothelial dysfunction. Rodent models that capture these early events are needed for mechanistic and interventional studies. This study evaluated whether a cholesterol-rich, high-fat diet (HFD) supplemented with vitamin D and propylthiouracil (PTU) promotes a pro-atherogenic phenotype in rats, as evidenced by dyslipidemia,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41923301
DOI: 10.1002/ame2.70178
PMCID: PMC13331555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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