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Article

FOXP3 germline polymorphisms are not associated with risk of breast cancer.

Cancer genetics and cytogenetics - 1 Apr 2009

Raskin Leon, Rennert Gad, Gruber Stephen B

Abstract excerpt

Recent studies have characterized X-linked transcriptional regulator FOXP3 as a tumor suppressor gene involved in the pathogenesis of breast cancer. A high rate of somatic FOXP3 mutations in breast tumors and the consequent upregulation of ERBB2 (alias HER-2) make FOXP3 a good candidate gene for breast cancer susceptibility. By taking advantage of a highly conserved FOXP3 sequence, we genotyped three...

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Source

Identifiers

PMID: 19264232
DOI: 10.1016/j.cancergencyto.2008.12.005

Genes

FOXP3
ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FOXP3 germline polymorphisms are not associated with risk of breast cancer.PMID 19264232Read ↗

FOXP3 promoter polymorphisms are not associated with a risk for breast cancer: a study from Egypt.Semantic proximity Read ↗

FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.Semantic proximity Read ↗

FOXP3 Allelic Variants and Haplotype Structures Are Associated with Aggressive Breast Cancer Subtypes.Semantic proximity Read ↗

No evidence that GATA3 rs570613 SNP modifies breast cancer risk.Semantic proximity Read ↗

FOXP3 transcription factor: a candidate marker for susceptibility and prognosis in triple negative breast cancer.Semantic proximity Read ↗

Foxp3 heterozygosity does not overtly affect mammary gland development during puberty or the oestrous cycle in mice.Semantic proximity Read ↗

Foxp3 promoter polymorphism (rs3761548) in breast cancer progression: a study from India.Semantic proximity Read ↗

FOXP3 polymorphisms in type 1 diabetes and coeliac disease.Semantic proximity Read ↗

Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status.Semantic proximity Read ↗

IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).Semantic proximity Read ↗

No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population.Semantic proximity Read ↗

Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors.Semantic proximity Read ↗

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