Article
Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors.
Breast cancer research and treatment - 1 Jan 2010
Arnold Jeremy M, Choong David Y H, Thompson Ella R, Waddell Nic, Lindeman Geoffrey J, Visvader Jane E, Campbell Ian G, Chenevix-Trench Georgia
Abstract excerpt
Heterozygous somatic mutations of the transcription factor, GATA-3, have recently been reported in approximately 5% breast of tumors unselected for family history. We sequenced the GATA-3 gene in 55 breast tumors from women with familial breast cancer, and found seven heterozygous somatic mutations, all in non-BRCA1/2 cases in which the frequency was 22%. In contrast, we found mutations of GATA-3 in only 4% of 81...
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