Article
No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population.
Diabetes - 1 Jul 2004
Zavattari Patrizia, Deidda Elisabetta, Pitzalis Maristella, Zoa Barbara, Moi Loredana, Lampis Rosanna, Contu Daniela, Motzo Costantino, Frongia Paola, Angius Efisio, Maioli Mario, Todd John A, Cucca Francesco
Abstract excerpt
Mutations of the forkhead/winged helix transcription factor FOXP3 gene on chromosome Xp11.23 cause a rare recessive monogenic disorder called IPEX (immune dysregulation, polyendocrinopathy, including type 1 diabetes, enteropathy, and X-linked syndrome). FOXP3 is necessary for the differentiation of a key immune suppressive subset of T-cells, the CD4+CD25+ regulatory T-cells. Previously, we reported a significant...
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