Association study and meta-analysis of Alzheimer's disease risk and presenilin-1 intronic polymorphism.

doi:10.1016/j.brainres.2007.07.032

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Association study and meta-analysis of Alzheimer's disease risk and presenilin-1 intronic polymorphism.

Brain research - 19 Sept 2007

Rodríguez-Manotas Miguel, Amorín-Díaz Manuel, Cañizares-Hernández Francisco, Ruíz-Espejo Francisco, Martínez-Vidal Salvadora, González-Sarmiento Rogelio, Martínez-Hernández Pedro, Cabezas-Herrera Juan

Abstract excerpt

Numerous studies have tested for associations between an intronic polymorphism (rs165932) of presenilin-1 (PS-1) gene and the risk of Alzheimer's disease (AD), but results have been conflicting. To throw light on this issue, we investigate the possible involvement of PS-1 genotype in a case-control study based on a relatively stable population in Spain and a meta-analysis of published studies. An examination was...

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PMID: 17719017
DOI: 10.1016/j.brainres.2007.07.032

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