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Article

Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling.

Journal of cell science - 1 Apr 2009

Cowell Catherine F, Döppler Heike, Yan Irene K, Hausser Angelika, Umezawa Yoshio, Storz Peter

Abstract excerpt

Increases in reactive oxygen species (ROS) have been implicated in age-related diseases, including cancer. The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor for reactive oxygen species, which can initiate cell survival through NF-kappaB signaling. We have previously shown that in response to ROS, PKD1 is activated at the mitochondria. However, the initial signaling...

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Source

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Identifiers

PMID: 19258390
DOI: 10.1242/jcs.041061
PMCID: PMC2720927

Genes

PKD1
PLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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