Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB.

Molecular pharmacology - 1 Oct 2004

Storz Peter, Döppler Heike, Toker Alex

Abstract excerpt

Activation of the inducible transcription factor nuclear factor kappaB (NF-kappaB) occurs in cells exposed to oxidative stress, and the serine/threonine kinase protein kinase D (PKD) is critical for signal relay to NF-kappaB. We have recently delineated two coordinated events that control PKD activation in response to oxidative stress: phosphorylation at Tyr463 by the tyrosine kinase Abl, and phosphorylation at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants
Share to NF-kappa B
Share to Protein Kinase C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Kinase C-delta

Share to Proto-Oncogene Proteins c-abl

Share to Resveratrol

Share to src-Family Kinases

Share to Stilbenes

Source

Identifiers

PMID: 15226414
DOI: 10.1124/mol.104.000687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB.PMID 15226414Read ↗

Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation.Semantic proximity Read ↗

Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus.Semantic proximity Read ↗

Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species.Semantic proximity Read ↗

Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling.Semantic proximity Read ↗

Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain.Semantic proximity Read ↗

Independence of protein kinase C-delta activity from activation loop phosphorylation: structural basis and altered functions in cells.Semantic proximity Read ↗

Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation.Semantic proximity Read ↗

Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation.Semantic proximity Read ↗

Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.Semantic proximity Read ↗

Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.Semantic proximity Read ↗

Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity.Semantic proximity Read ↗

Activation of protein kinase D3 by signaling through Rac and the alpha subunits of the heterotrimeric G proteins G12 and G13.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.