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Article

Oxidative stress-induced phospholipase C-gamma 1 activation enhances cell survival.

The Journal of biological chemistry - 27 Jul 2001

Wang X T, McCullough K D, Wang X J, Carpenter G, Holbrook N J

Abstract excerpt

Phospholipase C-gamma1 (PLC-gamma1) is rapidly activated in response to growth factor stimulation and plays an important role in regulating cell proliferation and differentiation through the generation of the second messengers diacylglycerol and inositol 1,4,5-trisphosphate, leading to the activation of protein kinase C (PKC) and increased levels of intracellular calcium, respectively. Given the existing overlap...

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Identifiers

PMID: 11350969
DOI: 10.1074/jbc.M102693200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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