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Article

Alternating access in maltose transporter mediated by rigid-body rotations.

Molecular cell - 27 Feb 2009

Khare Dheeraj, Oldham Michael L, Orelle Cedric, Davidson Amy L, Chen Jue

Abstract excerpt

ATP-binding cassette transporters couple ATP hydrolysis to substrate translocation through an alternating access mechanism, but the nature of the conformational changes in a transport cycle remains elusive. Previously we reported the structure of the maltose transporter MalFGK(2) in an outward-facing conformation in which the transmembrane (TM) helices outline a substrate-binding pocket open toward the...

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Identifiers

PMID: 19250913
DOI: 10.1016/j.molcel.2009.01.035
PMCID: PMC2714826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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