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Article

Nucleotide-dependent Allostery within the ABC Transporter ATP-binding Cassette

8 May 2007

Abstract excerpt

ATP-binding cassette transporters perform energy-dependent transmembrane solute trafficking in all organisms. These proteins often mediate cellular resistance to therapeutic drugs and are involved in a range of human genetic diseases. Enzymological studies have implicated a helical subdomain within the ATP-binding cassette nucleotide-binding domain in coupling ATP hydrolysis to solute transport in the...

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PMID: 17485460
DOI: 10.1074/jbc.m700809200

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