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Article

Uncoupling substrate transport from ATP hydrolysis in the Escherichia coli maltose transporter.

The Journal of biological chemistry - 17 Dec 2010

Cui Jinming, Qasim Sabiha, Davidson Amy L

Abstract excerpt

Members of the ATP-binding cassette superfamily couple the energy from ATP hydrolysis to the active transport of substrates across the membrane. The maltose transporter, a well characterized model system, consists of a periplasmic maltose-binding protein (MBP) and a multisubunit membrane transporter, MalFGK(2). On the basis of the structure of the MBP-MalFGK(2) complex in an outward-facing conformation (Oldham,...

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Identifiers

PMID: 20959448
DOI: 10.1074/jbc.M110.147819
PMCID: PMC3000980

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Uncoupling substrate transport from ATP hydrolysis in the Escherichia coli maltose transporter.PMID 20959448Read ↗

Studies of the maltose transport system reveal a mechanism for coupling ATP hydrolysis to substrate translocation without direct recognition of substrate.Semantic proximity Read ↗

Nucleotide-free MalK drives the transition of the maltose transporter to the inward-facing conformation.Semantic proximity Read ↗

Unliganded maltose-binding protein triggers lactose transport in an Escherichia coli mutant with an alteration in the maltose transport system.Semantic proximity Read ↗

Overproduction, solubilization, and reconstitution of the maltose transport system from Escherichia coli.Semantic proximity Read ↗

Mutation of a single MalK subunit severely impairs maltose transport activity in Escherichia coli.Semantic proximity Read ↗

Mechanism of maltose transport in Escherichia coli: transmembrane signaling by periplasmic binding proteins.Semantic proximity Read ↗

Alternating access in maltose transporter mediated by rigid-body rotations.Semantic proximity Read ↗

Discovery of an auto-regulation mechanism for the maltose ABC transporter MalFGK2.Semantic proximity Read ↗

A comparative electron paramagnetic resonance study of the nucleotide-binding domains' catalytic cycle in the assembled maltose ATP-binding cassette importer.Semantic proximity Read ↗

Mutations that alter the transmembrane signalling pathway in an ATP binding cassette (ABC) transporter.Semantic proximity Read ↗

The maltose ABC transporter: action of membrane lipids on the transporter stability, coupling and ATPase activity.Semantic proximity Read ↗

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