Article
Crystal structure of a catalytic intermediate of the maltose transporter.
Nature - 22 Nov 2007
Oldham Michael L, Khare Dheeraj, Quiocho Florante A, Davidson Amy L, Chen Jue
Abstract excerpt
The maltose uptake system of Escherichia coli is a well-characterized member of the ATP-binding cassette transporter superfamily. Here we present the 2.8-A crystal structure of the intact maltose transporter in complex with the maltose-binding protein, maltose and ATP. This structure, stabilized by a mutation that prevents ATP hydrolysis, captures the ATP-binding cassette dimer in a closed, ATP-bound...
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