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Article

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer.

Molecular cell - 1 Jul 2002

Smith Paul C, Karpowich Nathan, Millen Linda, Moody Jonathan E, Rosen Jane, Thomas Philip J, Hunt John F

Abstract excerpt

It has been proposed that the reaction cycle of ATP binding cassette (ABC) transporters is driven by dimerization of their ABC motor domains upon binding ATP at their mutual interface. However, no such ATP sandwich complex has been observed for an ABC from an ABC transporter. In this paper, we report the crystal structure of a stable dimer formed by the E171Q mutant of the MJ0796 ABC, which is hydrolytically...

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Identifiers

PMID: 12150914
DOI: 10.1016/s1097-2765(02)00576-2
PMCID: PMC3516284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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