Article
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.
Cell - 24 Nov 2004
Sanders Steven L, Portoso Manuela, Mata Juan, Bähler Jürg, Allshire Robin C, Kouzarides Tony
Abstract excerpt
Histone lysine methylation is a key regulator of gene expression and heterochromatin function, but little is known as to how this modification impinges on other chromatin activities. Here we demonstrate that a previously uncharacterized SET domain protein, Set9, is responsible for H4-K20 methylat...
Topics
- Cell Cycle Proteins
- Cell Survival
- DNA Damage
- Gene Expression Regulation, Fungal
- Genes, cdc
- Histone Methyltransferases
- Histone-Lysine N-Methyltransferase
- Histones
- Intracellular Signaling Peptides and Proteins
- Lysine
- Methylation
- Mutation
- Nuclear Proteins
- Phosphoproteins
- Protein Methyltransferases
- Protein Transport
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins