DNA-lesion mapping in mammalian cells.

doi:10.1016/j.ymeth.2009.02.008

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Article

DNA-lesion mapping in mammalian cells.

Methods (San Diego, Calif.) - 1 May 2009

Besaratinia Ahmad, Pfeifer Gerd P

Abstract excerpt

Formation of DNA damage is a crucial event in carcinogenesis. Irreparable DNA lesions have the potential to cause mispairing during DNA replication, thereby giving rise to mutations. Critically important mutations in cancer-related genes, i.e., oncogenes and tumor suppressor genes, are key contributors to carcinogenesis. Theoretically, co-localization(s) of persistent DNA lesions and mutational hotspots in...

Topics

Animals
Base Pairing
Base Sequence
Carcinogens
Cell Transformation, Neoplastic
Cells
DNA
DNA Adducts
DNA Damage
DNA Footprinting
DNA Ligases
DNA Mutational Analysis
DNA Primers
Genes, p53
Genome, Human
Humans
Mammals
Mutagenesis

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Identifiers

PMID: 19245834
DOI: 10.1016/j.ymeth.2009.02.008
PMCID: PMC2693248

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