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Article

PCR-based approaches to adduct analysis.

Toxicology letters - 28 Dec 1998

Pfeifer G P, Denissenko M F, Tang M S

Abstract excerpt

Ligation-mediated polymerase chain reaction (LMPCR) is a PCR-based method for the detection of DNA adducts at individual nucleotide positions in mammalian genes. Adduct-specific enzymes, such as T4 endonuclease V, various base excision repair enzymes, UvrABC nuclease, and chemical cleavage techniques can be used to convert the adducts into DNA strand breaks. The positions of these breaks are then detected by...

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PMID: 10022294
DOI: 10.1016/s0378-4274(98)00337-3

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