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The HLTF–PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate

7 Dec 2020

Abstract excerpt

Human HLTF participates in the lesion-bypass mechanism through the fork reversal structure, known as template switching of post-replication repair. However, the mechanism by which HLTF promotes the replication progression and fork stability of damaged forks remains unclear. Here, we identify a novel protein-protein interaction between HLTF and PARP1. The depletion of HLTF and PARP1 increases chromosome breaks,...

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PMID: 33281189
DOI: 10.1038/s41389-020-00289-5

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