Article
Do schizophrenia and bipolar disorders share a common disease susceptibility variant at the MMP3 gene?
Progress in neuro-psychopharmacology & biological psychiatry - 30 Apr 2009
Kucukali Cem Ismail, Aydin Makbule, Ozkok Elif, Bilge Emine, Orhan Nurcan, Zengin Asli, Kara Ihsan
Abstract excerpt
There is growing evidence of partial etiological overlap between schizophrenia (SZ) and bipolar I disorder (BD-I) from linkage analysis, genetic epidemiology and molecular genetics studies. SZ and BD-I are neurodevelopmental disorders with genetic and environmental etiologies. Recent studies have demonstrated that matrix metalloproteinase 3 (MMP3) is a key event in associative memory formation, learning and...
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