Article
Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Aug 2004
Zhang Yanbo, Yu Xin, Yuan Yanbo, Ling Yansu, Ruan Yan, Si Tianmei, Lu Tianlian, Wu Suping, Gong Xiaohong, Zhu Zhongjun, Yang Jianzhong, Wang Fei, Zhang Dai
Abstract excerpt
Frizzled 3 (FZD3) gene is located on chromosome 8p21, a region that has been implicated in schizophrenia in genetic linkage studies. The FZD3 is a transmembrane receptor required for Wnt signal transduction cascades that have been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Previous work has showed a strong association between FZD3 locus and schizophrenia in...
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