Article
The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.
Neuroscience letters - 15 Dec 2003
Katsu Takeshi, Ujike Hiroshi, Nakano Takamitsu, Tanaka Yuji, Nomura Akira, Nakata Kenji, Takaki Manabu, Sakai Ayumu, Uchida Naohiko, Imamura Takaki, Kuroda Shigetoshi
Abstract excerpt
Neurodevelopmental abnormalities have been reported in studies on the pathogenesis of schizophrenia. The Wnt-signaling pathway has been implicated in a variety of processes in neurodevelopment, and the frizzled proteins have been identified as receptors for Wnt ligands. Of the frizzled proteins, frizzled-3 (FZD3) is required for formation of the neural crest and for development of major fiber tracts in the CNS....
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