Article
Common variants in FCER1A influence total serum IgE levels from cord blood up to six years of life.
Allergy - 1 Sept 2009
Chen C-M, Weidinger S, Klopp N, Sausenthaler S, Bischof W, Herbarth O, Bauer M, Borte M, Schaaf B, Lehmann I, Behrendt H, Krämer U, Berdel D, von Berg A, Bauer C P, Koletzko S, Illig T, Wichmann H-E, Heinrich J
Abstract excerpt
BACKGROUND: In a recent genome wide scan, a functional promoter variant (rs2251746) in the gene encoding the alpha chain of the high affinity receptor for immunoglobulin E (IgE) (FCER1A) was identified as major determinant of serum IgE levels. OBJECTIVE: The aim of this study was to investigate the role of rs2251746 on total IgE levels measured at different stages of life from birth (cord blood) up to the age of...
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