Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.

doi:10.1371/journal.pgen.1000166

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Article

Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.

PLoS genetics - 1 Aug 2008

Weidinger Stephan, Gieger Christian, Rodriguez Elke, Baurecht Hansjörg, Mempel Martin, Klopp Norman, Gohlke Henning, Wagenpfeil Stefan, Ollert Markus, Ring Johannes, Behrendt Heidrun, Heinrich Joachim, Novak Natalija, Bieber Thomas, Krämer Ursula, Berdel Dietrich, von Berg Andrea, Bauer Carl Peter, Herbarth Olf, Koletzko Sibylle, Prokisch Holger, Mehta Divya, Meitinger Thomas, Depner Martin, von Mutius Erika, Liang Liming, Moffatt Miriam, Cookson William, Kabesch Michael, Wichmann H-Erich, Illig Thomas

Abstract excerpt

High levels of serum IgE are considered markers of parasite and helminth exposure. In addition, they are associated with allergic disorders, play a key role in anti-tumoral defence, and are crucial mediators of autoimmune diseases. Total IgE is a strongly heritable trait. In a genome-wide association study (GWAS), we tested 353,569 SNPs for association with serum IgE levels in 1,530 individuals from the...

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PMID: 18846228
DOI: 10.1371/journal.pgen.1000166
PMCID: PMC2565692

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RAD50
STAT6

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