Article
Genetic variability of the high-affinity IgE receptor alpha subunit (Fc epsilon RI alpha) is related to total serum IgE levels in allergic subjects.
Allergology international : official journal of the Japanese Society of Allergology - 1 Dec 2007
Sanak Marek, Potaczek Daniel P, Nizankowska-Mogilnicka Ewa, Szczeklik Andrew
Abstract excerpt
Known susceptibility genes to atopy and asthma have been identified by linkage or associations with clinical phenotypes, including total serum IgE levels. IgE-mediated sensitivity reactions require a high-affinity IgE receptor (FcepsilonRI), which immobilizes the immunoglobulin on the surface of the effector cells, mostly mast cells and basophils. In this mini-review, recent findings are presented on genetic...
Topics
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Hypersensitivity
- Immunoglobulin E
- Polymorphism, Single Nucleotide
- Protein Subunits
- Receptors, IgE