Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.

doi:10.1016/j.jaci.2023.10.023

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Article

Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.

The Journal of allergy and clinical immunology - 1 Mar 2024

Clay Selene, Alladina Jehan, Smith Neal P, Visness Cynthia M, Wood Robert A, O'Connor George T, Cohen Robyn T, Khurana Hershey Gurjit K, Kercsmar Carolyn M, Gruchalla Rebecca S, Gill Michelle A, Liu Andrew H, Kim Haejin, Kattan Meyer, Bacharier Leonard B, Rastogi Deepa, Rivera-Spoljaric Katherine, Robison Rachel G, Gergen Peter J, Busse William W, Villani Alexandra-Chloe, Cho Josalyn L, Medoff Benjamin D, Gern James E, Jackson Daniel J, Ober Carole, Dapas Matthew

Abstract excerpt

BACKGROUND: Most genetic studies of asthma and allergy have focused on common variation in individuals primarily of European ancestry. Studying the role of rare variation in quantitative phenotypes and in asthma phenotypes in populations of diverse ancestries can provide additional, important insights into the development of these traits. OBJECTIVE: We sought to examine the contribution of rare variants to...

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Identifiers

PMID: 37944567
DOI: 10.1016/j.jaci.2023.10.023
PMCID: PMC10939893

Genes

TNFRSF21

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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