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Article

Thyroid stimulating hormone receptor (TSHR) intron 1 variants are major risk factors for Graves' disease in three European Caucasian cohorts.

PloS one - 25 Nov 2010

Płoski Rafał, Brand Oliver J, Jurecka-Lubieniecka Beata, Franaszczyk Maria, Kula Dorota, Krajewski Paweł, Karamat Muhammad A, Simmonds Matthew J, Franklyn Jayne A, Gough Stephen C L, Jarząb Barbara, Bednarczuk Tomasz

Abstract excerpt

BACKGROUND: The thyroid stimulating hormone receptor (TSHR) gene is an established susceptibility locus for Graves' disease (GD), with recent studies refining association to two single nucleotide polymorphisms (SNPs), rs179247 and rs12101255, within TSHR intron 1. METHODOLOGY AND PRINCIPAL FINDINGS: We aimed to validate association of rs179247 and rs12101255 in Polish and UK Caucasian GD case-control subjects,...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21124799
DOI: 10.1371/journal.pone.0015512
PMCID: PMC2991361

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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