Article
Genome-scale search of tumor-specific antigens by collective analysis of mutations, expressions and T-cell recognition.
Molecular immunology - 1 May 2009
Jia Jia, Cui Juan, Liu Xianghui, Han Jinhua, Yang Shengyong, Wei Yuquan, Chen Yuzong
Abstract excerpt
BACKGROUND: Tumor-specific antigens (TSAs) are potential sources of cancer vaccines, some of which are derived from T-cell epitopes of over-expressed mutant proteins to elicit immunogenicity and overcome tolerance and evasion. The lack of effective vaccines for many cancers has prompted strong interest in improved TSA search methods. Recent progresses in profiling somatic mutations and expressions of human cancer...
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