Shared neoantigens' atlas for off-the-shelf cancer vaccine development.

Abstract excerpt

BACKGROUND: We have recently described that the most prevalent 100 mutations identified in human cancers, both single nucleotide variations (SNVs) and InDels, generate a handful number of shared mutated neoantigens (SNV and InDel-NeoAgs) in association with 5 HLA-A and 7 B haplotypes. METHODS: In the present study, we expanded such analysis to 50 haplotypes in the three MHC class I loci (10 HLA-A, 27 HLA-B and 13...

Topics

• Humans
• Cancer Vaccines
• Antigens, Neoplasm
• Haplotypes
• Neoplasms
• Vaccine Development
• Mutation