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Article

Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies.

Genome medicine - 24 Feb 2017

Hartmaier Ryan J, Charo Jehad, Fabrizio David, Goldberg Michael E, Albacker Lee A, Pao William, Chmielecki Juliann

Abstract excerpt

BACKGROUND: The integration of genomics with immunotherapy has potential value for cancer vaccine development. Given the clinical successes of immune checkpoint modulators, interest in cancer vaccines as therapeutic options has been revived. Current data suggest that each tumor contains a unique set of mutations (mutanome), thus requiring the creation of individualized cancer vaccines. However, rigorous analysis...

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Identifiers

PMID: 28231819
DOI: 10.1186/s13073-017-0408-2
PMCID: PMC5324279

Genes

KRAS
EGFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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