Identification of Individual Cancer-Specific Somatic Mutations for Neoantigen-Based Immunotherapy of Lung Cancer.

doi:10.1016/j.jtho.2015.11.006

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Article

Identification of Individual Cancer-Specific Somatic Mutations for Neoantigen-Based Immunotherapy of Lung Cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Mar 2016

Karasaki Takahiro, Nagayama Kazuhiro, Kawashima Mitsuaki, Hiyama Noriko, Murayama Tomonori, Kuwano Hideki, Nitadori Jun-ichi, Anraku Masaki, Sato Masaaki, Miyai Manami, Hosoi Akihiro, Matsushita Hirokazu, Kikugawa Shingo, Matoba Ryo, Ohara Osamu, Kakimi Kazuhiro, Nakajima Jun

Abstract excerpt

INTRODUCTION: Two strategies for selecting neoantigens as targets for non-small cell lung cancer vaccines were compared: (1) an "off-the-shelf" approach starting with shared mutations extracted from global databases and (2) a personalized pipeline using whole-exome sequencing data on each patient's tumor. METHODS: The Catalogue of Somatic Mutations in Cancer database was used to create a list of shared missense...

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Identifiers

PMID: 26752676
DOI: 10.1016/j.jtho.2015.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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