Article

HLA class I restricted epitopes prediction of common tumor antigens in Caucasoid and Oriental ethnic populations: implication on antigen selection for tumor specific CD8+ T cellular immunotherapy and cancer vaccine design

2019-06-13

Abstract excerpt

<h4>Background: </h4> Tumor antigens processed and presented by human leukocyte antigen (HLA) Class I alleles are important targets in tumor immunotherapy. Clinical trials showed that CD8+ T cells specific to tumor associated antigens (TAAs) and tumor neoantigens is one of the main factors resulting tumor regression. Affinity prediction of tumor antigen epitopes to HLA is an important reference index for peptide s...

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Literature Corpus work: 69383612-df52-53ca-aae2-702d1cc04090
DOI: 10.21203/rs.2.10261/v1

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