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Mutations in Bacchus reveal a tyramine-dependent nuclear regulator for acute ethanol sensitivity in Drosophila.

Neuropharmacology - 1 Apr 2013

Chen Jiang, Wang Yonghua, Zhang Yan, Shen Ping

Abstract excerpt

Fruit flies and humans display remarkably similar behavioral responses to ethanol intoxication. Here we report that loss-of-function mutations in the CG9894 gene (now named Bacchus or Bacc) attenuate ethanol sensitivity in flies. Bacc encodes a broadly expressed nuclear protein with a motif similar to ribosomal RNA-binding domains. The ethanol-related activity of Bacc was mapped to Tdc2-GAL4 neurons. Genetic and...

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PMID: 23142736
DOI: 10.1016/j.neuropharm.2012.10.013

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