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Article

Inherited variability of tumor necrosis factor production and susceptibility to infectious disease.

Proceedings of the Association of American Physicians - 1 Jan 2000

Knight J C, Kwiatkowski D

Abstract excerpt

Tumor necrosis factor (TNF) is a critical mediator of host defense against infection but may cause severe pathology when produced in excess. Individuals vary in the amount of TNF produced when their peripheral blood mononuclear cells are stimulated in vitro, and family studies indicate that much of this variability is genetically determined. Since the TNF response to infection is partly regulated at the...

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Identifiers

PMID: 10417736
DOI: 10.1046/j.1525-1381.1999.99237.x

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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