Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic determinants of the inflammatory response.

Current opinion in critical care - 1 Oct 2004

Imahara Scott D, O'Keefe Grant E

Abstract excerpt

PURPOSE OF REVIEW: Despite substantial advances in our understanding of the biology of sepsis and inflammation, improvements in clinical outcomes have been more sporadic and, with few notable exceptions, are related to improvements in supportive care rather than to specific therapies. As a result, morbidity, mortality, and cost remain high. Investigation into the genetic determinants of this response span a broad...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Toll-Like Receptors
Share to Tumor Necrosis Factor-alpha
Share to Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Glycoproteins

Share to Polymorphism, Single Nucleotide

Share to Receptors, Cell Surface

Share to Sepsis

Share to Toll-Like Receptor 4

Source

Identifiers

PMID: 15385745
DOI: 10.1097/01.ccx.0000140942.42247.7e

Genes

TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic determinants of the inflammatory response.PMID 15385745Read ↗

Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy.Semantic proximity Read ↗

Bench-to-bedside review: understanding genetic predisposition to sepsis.Semantic proximity Read ↗

Genetic polymorphisms and sepsis.Semantic proximity Read ↗

Genomic polymorphisms in sepsisSemantic proximity Read ↗

Bench-to-bedside review: Association of genetic variation with sepsis.Semantic proximity Read ↗

Genetic insights into sepsis: what have we learned and how will it help?Semantic proximity Read ↗

Genetic polymorphisms in sepsis.Semantic proximity Read ↗

Host genetic variants in sepsis risk: a field synopsis and meta-analysisSemantic proximity Read ↗

Circulating inflammatory cytokines and the risk of sepsis: a bidirectional mendelian randomization analysis.Semantic proximity Read ↗

Genetic polymorphisms in sepsis.Semantic proximity Read ↗

Genetic polymorphisms, biomarkers and signaling pathways associated with septic shock: from diagnosis to therapeutic targetsSemantic proximity Read ↗

Genetically predicted the causal association between circulating inflammatory proteins and sepsisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.