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Article

Overexpression of Wnt-2 in colorectal cancers

1 Jan 2009

Abstract excerpt

UNLABELLED: The binding of the Wnt ligand to its receptor Frizzled, activates the Wnt canonical signaling pathway in carcinogenesis as well as many cellular processes, including cellular proliferation and differentiation. Wnt-2, one of 19 members of the <em>Wnt</em> gene family, is frequently overexpressed in malignant tissues. Here, in order to investigate the role of Wnt-2 in colorectal carcinogenesis, we...

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PMID: 19239325
DOI: 10.4149/neo_2009_02_119

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