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Article

[Mechanism of Wnt signaling pathway regulation by a truncated mutant of Axin2 in colorectal cancer].

Ai zheng = Aizheng = Chinese journal of cancer - 1 Oct 2007

Wang Feng-Wei, Wen Ling, Zhu Si-Wei, Yao Qiang, Cai Yu-Mei, Ma Gang

Abstract excerpt

BACKGROUND & OBJECTIVE: Axin2 gene which negatively regulates the Wnt signaling pathway was cloned recently. A truncated mutation of Axin2 (mtAxin2) is the most common mutation pattern in colorectal cancer (CRC) and could enhance the luciferase activity of T-cell factor (TCF). This study was to explore the mechanism of Wnt signaling pathway regulation by mtAxin2 in CRC. METHODS: The expression of beta-catenin in...

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PMID: 17927870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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