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Article

Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma

1 Aug 2002

Abstract excerpt

AIMS: Signalling through the Wnt pathway is integrally associated with colon carcinogenesis. Although activating mutations in the genes for adenomatous polyposis coli (APC) and beta-catenin are clearly associated with colon cancer, less is understood about the role of the upstream secreted ligands (Wnts) and their receptors (frizzled, Fz) in this process. In other systems, increased Wnt signalling has been shown...

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PMID: 12147710
DOI: 10.1136/mp.55.4.220

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