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Article

Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy.

The pharmacogenomics journal - 1 Jun 2009

Furihata Tomomi, Satoh Naoki, Ohishi Tomoharu, Ugajin Miyuki, Kameyama Yoshio, Morimoto Kaori, Matsumoto Sayaka, Yamashita Keiko, Kobayashi Kaoru, Chiba Kan

Abstract excerpt

In the present study, we analyzed the function of a novel mutation (c.1628T>G, p.Leu543Trp) in the solute carrier organic anion transporter (SLCO) 1B1 gene, encoding organic anion transporting polypeptide (OATP) 1B1, which was identified in a patient with pravastatin-induced myopathy. OATP1B1 variants carrying the mutation (OATP1B1*1a+c.1628T>G or *1b+c.1628T>G) showed a reduced transporting activity toward...

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PMID: 19238167
DOI: 10.1038/tpj.2009.3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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