Article
The role of the CD58 locus in multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 2009
De Jager Philip L, Baecher-Allan Clare, Maier Lisa M, Arthur Ariel T, Ottoboni Linda, Barcellos Lisa, McCauley Jacob L, Sawcer Stephen, Goris An, Saarela Janna, Yelensky Roman, Price Alkes, Leppa Virpi, Patterson Nick, de Bakker Paul I W, Tran Dong, Aubin Cristin, Pobywajlo Susan, Rossin Elizabeth, Hu Xinli, Ashley Charles W, Choy Edwin, Rioux John D, Pericak-Vance Margaret A, Ivinson Adrian, Booth David R, Stewart Graeme J, Palotie Aarno, Peltonen Leena, Dubois Bénédicte, Haines Jonathan L, Weiner Howard L, Compston Alastair, Hauser Stephen L, Daly Mark J, Reich David, Oksenberg Jorge R, Hafler David A
Abstract excerpt
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with demyelination and axonal loss. A whole genome association scan suggested that allelic variants in the CD58 gene region, encoding the costimulatory molecule LFA-3, are associated with risk of developing MS. We now report additional genetic evidence, as well as resequencing and fine mapping of the CD58 locus in patients...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.