Article
Protective C allele of the single-nucleotide polymorphism rs1335532 is associated with strong binding of Ascl2 transcription factor and elevated CD58 expression in B-cells.
Biochimica et biophysica acta. Molecular basis of disease - 1 Oct 2018
Mitkin Nikita A, Muratova Alisa M, Korneev Kirill V, Pavshintsev Vsevolod V, Rumyantsev Konstantin A, Vagida Murad S, Uvarova Aksinya N, Afanasyeva Marina A, Schwartz Anton M, Kuprash Dmitry V
Abstract excerpt
CD58 is expressed on the surface of antigen-presenting cells, including B-cells, and provides co-stimulation to regulatory T-cells (Treg) through CD2 receptor binding. Tregs appear to be essential suppressors of tissue-specific autoimmune responses. Thereby, CD58 plays protective role in multiple sclerosis (MS) and CD58 was identified among several loci associated with MS susceptibility. Minor (C) variant of the...
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