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Article

rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases.

Human genetics - 1 Jan 2024

Hitomi Yuki, Ueno Kazuko, Aiba Yoshihiro, Nishida Nao, Kawai Yosuke, Kawashima Minae, Khor Seik-Soon, Takada Sanami, Iwabuchi Chisato, Nagasaki Masao, Tokunaga Katsushi, Nakamura Minoru

Abstract excerpt

CD58 plays roles in cell adhesion and co-stimulation with antigen presentation from major histocompatibility complex class II on antigen-presenting cells to T-cell antigen receptors on naïve T cells. CD58 reportedly contributes to the development of various human autoimmune diseases. Recently, genome-wide association studies (GWASs) identified CD58 as a susceptibility locus for autoimmune diseases such as...

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PMID: 37994973
DOI: 10.1007/s00439-023-02617-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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